LC/MS/MS is the methodology of choice for small molecule drug quantitation. The molecular weight "cut-off" for a small molecule has changes through out the years of LC/MS/MS evolution. By definition any molecules that can be ionized and detected can be quantitated by LC/MS/MS. Although most of the LC/MS/MS methods QPS developed and validated are for the traditional small molecules drugs, we have developed and validated LC/MS/MS assays for large multiply charged molecules.

Examples are: "4-in-1" quantitation of human insulin pro-drug and its catabolites (5,500 Da); an endogenous polypeptide of around 4,500 Da as a clinical surrogate endpoint using immuno-affinity LC/MS/MS; an oligonucleotides of around 4,500 Da.

QPS currently has 37 LC/MS/MS instruments between QPS-US and QPS-Taiwan. QPS-US has 24 triple quadrupoles mass spectrometers and as well as LC/UV and LC/fluorescence instruments dedicated to GLP studies. 9 other LC/MS/MS including triple quadrupoles and linear ion trap are dedicated to discovery, non-GLP, and metabolite identification studies. QPS-Taiwan has 4 LC/MS/MS instrument for GLP studies.

In addition, QPS employs state-of-the-art-automated equipment for sample preparation, and validated Watson LIMS, insuring superior data/report accuracy and quick turnaround. QPS has a proven record of providing timely, high quality data at competitive prices.